MEDICAL DEVICE DISINFECTION—HOW TO PREVENT CRACKING AND CRAZING Understanding polymer performance is key to minimizing disinfectant-related failures DISINFECTANT-RELATED DAMAGE ON POLYMER HOUSINGS Strong chemicals used to reduce hospital- acquired infections can damage equipment and result in material failures, such as: • Stress cracking • Crazing • Discoloration CHEMICAL RESISTANCE REQUIREMENTS VARY BY ENVIRONMENT • Patient/exam rooms • Operating and radiology rooms • Reception areas • Home (patient equipment & devices) Healthcare devices must perform flawlessly in a myriad of challenging environments and engineers must be certain their devices can withstand increasingly potent disinfectants, which have begun to outstrip the performance of traditional polymers. Additionally, the wide variability of environments that medical devices might see, which can range from home to hospital, mean devices must be able to withstand varying disinfectant strengths, exposure levels and frequencies. Whether you are designing for a medical device housing or a surgical device in the operating room, we offer solutions to meet a wide variety of performance specifications and application needs.

You may recognize the two healthcare megatrends that are driving global demand for pharmaceutical packaging, medical devices and drug delivery devices: economic gains in developing nations and an aging global population that requires treatment for chronic conditions. Ergonomic Enhancements TPE soft grips can also optimize medical practitioners’ control of surgical instruments during procedures and protect expensive handheld diagnostic devices. Pharmaceutical and medical device companies like yours are looking for new strategies to improve operational efficiencies so you can meet current requirements and scale up for the future.

Mevopur™ Healthcare Functional Additives for Pharmaceutical Packaging Mevopur™ Healthcare Functional Additives help protect and enhance the performance of polymers used in pharmaceutical packaging products such as vials, bottles, closure systems, films and combination devices. It is the responsibility of the medical device manufacturer and the person placing the medical device on the market to ensure compliance of the medical device with all applicable laws and regulations, including the suitability of all raw materials and components used for its manufacture. Please be aware that there are certain applications Avient’s Mevopur products have not been designed for, nor are they promoted or intended for use in: including, but not limited to long-term or permanent implants, birth control devices, or plastic surgery.

It is the responsibility of the medical device manufacturer and the person placing the medical device on the market to ensure compliance of the medical device with all applicable laws and regulations, including the suitability of all raw materials and components used for its manufacture. Please be aware that there are certain applications Avient’s Mevopur products have not been designed for, nor are they promoted or intended for use in: including, but not limited to long-term or permanent implants, birth control devices, or plastic surgery.

Improve patient experience with specialty polymers designed to optimize handling of the device Requirements: Thermal conductivity for warming of medicants Trilliant™ Therma-Tech™ Thermally Conductive Formulations Heating system 13 Heat Exchanger 14 Technology Enabled Design Connected medical devices are transforming the way care is delivered by making it simpler, easier, more collaborative, and more data driven. Smart health devices improve patient medication adherence and monitoring

SPECIALTY ENGINEERED MATERIALS FOR HEALTHCARE PRODUCT SELECTION GUIDE Careful consideration must be given to materials used for medical devices and their impact on patient safety. Common applications include medical device overmolds, medical and biopharma tubing, and gaskets and stoppers. These customizable materials include chemically resistant polymers to prevent device cracking, electrically conductive materials for consistent measuring, and high-density formulations to replace lead.

KEY CHARACTERISTICS • Manufactured at four ISO 13485 certified sites, providing global consistency and increased security of supply • Documented change control beyond CAS number, reducing risk of change • Non-phthalate and formulated without animal-derived substances • Color can be combined with additives to enhance performance and protection REGULATORY SUPPORT • Raw materials tested to: - ISO 10993-1 and USP biological evaluation - European Pharmacopeia 3.1.3/3.1.5 (polyolefin) - USP (polyethylene) - ICH Q3D elemental impurities • Registered Device Master File • Food contact established with FDA/EU* NOMINAL OUTSIDE DIAMETER OF NEEDLE (MM) COLOR DESCRIPTION RAL PANTONE TRANSPARENT PRODUCT CODE OPAQUE PRODUCT CODE 0.4 Medium Grey 7035 423 C PP7M665125 PP7M665127 0.45 Brown 8017 7588 C PP8M665294 PP8M665296 0.5 Orange 2003 173 C PP2M665298 PP2M665300 0.55 Medium Purple 4005 7676 C PP4M665290 PP4M665292 0.6 Deep Blue 5010 288 C PP5M665894 PP5M665896 0.7 Black 9005 Black C PP9M664950 PP9M664952 0.8 Deep Green 6001 7483 C PP6M665687 PP6M665689 0.9 Yellow 1021 115 C PP1M665211 PP1M665213 1.1 Cream 1015 7401 C PP0M665290 PP0M665292 1.2 Pink 3015 502 C PE3M665725 PP3M665727 Healthcare use limitations apply—see below. It is the responsibility of the medical device manufacturer and the person placing the medical device on the market to ensure compliance of the medical device with all applicable laws and regulations, including the suitability of all raw materials and components used for its manufacture. Please be aware that there are certain applications Avient’s Mevopur products have not been designed for, nor are they promoted or intended for use in: including, but not limited to long-term or permanent implants, birth control devices, or plastic surgery.

Surgical instruments and medical device components Medical, fiber optic and oil & gas connectors

Disinfectant Resistance for Medical Device Housings - Case Study Manufacturer boosts disinfectant resistance for medical device housings using Trilliant HC High Performance Formulations

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