Mevopur™ Healthcare Bio-based Polymer Solutions for Medical Devices and Pharmaceutical Packaging Manufacturers of medical devices and pharmaceutical packaging are increasingly faced with the challenge of integrating sustainability into the design of their products. Bio-polymers are already used with success in different plastic products, notably in packaging, but to be used in healthcare applications, they need to be evaluated to the relevant protocols to support regulatory compliance of the end article. KEY CHARACTERISTICS • Available for polyethylene, polypropylene, ABS, polycarbonate and styrenics • Bio-content of resin carrier varies from 70% to 100% depending on polymer—calculated to ASTM D6866 standard • Manufactured at four ISO 13485 certified sites, providing global consistency and security of supply • Documented change control beyond CAS number, reducing risk of change • Drop-in solutions that can be processed like fossil-based grades on common injection molding and extrusion machines • Can be provided as ready-to-use pre-colored or additive formulation REGULATORY SUPPORT • Raw materials tested to: - ISO 10993-1 - USP and (incl. class VI) - European Pharmacopeia, monograph 3.1.3/ 3.1.5 (polyolefin packaging materials) - USP (polyethylene) - Elemental impurities as per ICH Q3D • Registered Drug Master File (Type III) and/or Device Master File • Food contact according to US FDA and APPLICATION BULLETIN Sustainability Spotlight Bio-polymers Healthcare use limitations apply—see below.

RECYCLABILITY & rPET Brand owners wishing to operate with a Circular Economy need to use higher levels of rPET in their packaging. In order to satisfy the demand for a circular economy, governments are legislating increased use of recycled material in single use packaging. Amosorb 4020R improves the aesthetics of recycled packaging in terms of haze and color, and also maintains performance levels irrespective of the level of rPET used, delivering consistent results at all levels of rPET; 25%, 50% and 100%.

An addition to the Mevopur™ portfolio is a pre-tested amber concentrate for PET vials, bottles and other packaging products. Amber shades are known to offer effective protection from certain wavelengths, but the technologies of most amber polymer solutions on the market do not have regulatory support to comply with the pharmaceutical packaging regulations. Mevopur Healthcare Colorants and Formulations in amber tones provide the safety of pre-tested raw materials while protecting and prolonging the shelf life of pharmaceuticals and nutraceuticals in amber PET packaging products.

The food and beverage market has taken on many challenges within this capacity, with the aim of conciliating a need for preserving the integrity and nutritional characteristics in packaged goods throughout their required shelf life, and at the same time allowing full circularity of the packaging used to distribute such goods into the market. The European Union has encouraged and acted on the need for circular packaging by implementing many initiatives, including mandating legislation in order to achieve an ambitious target of 25% rPET being utilized in PET packaging by the year 2025, and then scaling this figure up to 30% for the overall plastic packaging industry by 2030.1 With 47% of PET demand in Europe used to produce bottles,2 it is no surprise PET has long been at the center of this green revolution. Active and passive oxygen barriers are additives that are broadly used in the PET bottle industry, across the value chain; they guarantee the optimal shelf life of packaged goods such as beer, juices, RTD beverages, or condiments, to name a few.

• Products are precision-wound for solid package integrity and minimal balooning, which yields the greatest length per package Packaging FIBER-LINE® Ripcords are supplied on a variety of cardboard tubes to meet your equipment needs. Packages can be supplied on colored, embossed and/or slit tubes.

Mevopur™ Healthcare Functional Additives for Pharmaceutical Packaging Mevopur™ Healthcare Functional Additives help protect and enhance the performance of polymers used in pharmaceutical packaging products such as vials, bottles, closure systems, films and combination devices. KEY CHARACTERISTICS • Manufactured at four ISO 13485 certified sites, providing global consistency and increased security of supply • Documented change control beyond CAS number, reducing risk of change • Non-phthalate and formulated without animal- derived substances • Available for use in a wide range of polymers including polyolefins, styrenics, polycarbonate and alloys, polyester, POM • Functionality can be combined with colorants into convenient combination concentrates or formulations REGULATORY SUPPORT • Pre-tested raw materials: - ISO 10993-1 and USP biological evaluation - European Pharmacopeia 3.1.3/3.1.5 (polyolefin) - USP (polyethylene) - ICH Q3D elemental impurities • Registered Drug Master File (Type III) • Food contact established with FDA/EU* APPLICATION BULLETIN * FDA/EU compliance information available upon request FUNCTIONALITY TARGET APPLICATIONS EBM/IBM CONTAINERS CLOSURES FILM COMBINATION DEVICES Clarifying PP Sorbitol-free—possibilities in packaging ocular solutions    Slip/torque reduction Slip for PE, PP films, processing aid, torque reduction for closures   Protection from UV in transparent packaging for PP, PE, PETG, COP UV blocking in 290–450nm with no impact on clarity    Antistatic ready-to-use solution for PE films e.g.

PROCESSING & HANDLING SmartHeat RHC is supplied in Avient’s ColorMatrix approved packaging and is active as supplied. STORAGE It is recommended that packages of SmartHeat RHC are stored under ambient conditions (between 10°C and 25°C) for optimal storage stability and dosing. EU FDA Mercosur SmartHeat RHC Yes Yes Yes PACKAGING Package Type Quantity 5G Pail Up to 40 lbs Planetpak Up to 40 lbs Test Description Test Method Units Typical Values Viscosity Avient Method cP 6,000–10,000 Density Avient Method Lbs/gal 7.9–8.9 Color Variance Avient Method ∆E 0.0–1.0 Color Appearance Visual — Slight Blue Dispersion Pressout Visual — Pass Opacity: Visual Visual — Pass TYPICAL GENERAL PROPERTIES1 1Typical values are not to be construed as specifications.

ULTRAVIOLET (UV) LIGHT BARRIER ADDITIVES Challenge: UV rays can degrade package contents, resulting in shorter shelf life. COLORS & EFFECTS Challenge: Secondary finishes such as electroplating, spray coatings and paints negate a package’s ability to be recycled. Likewise, black polymers are difficult to recycle using automatic sorting equipment, but special colorants can permit black packaging to be detected and recycled.

PACKAGING COMPONENT MANUFACTURER P E R F U M E C A P • A density modified formulation - PP filled, 1,2g/cm3 • Needs to contain recycled PP PIR content • Electroplatable - comparable to prime materials • Provide continuity of supply • Utilized formulation expertise to develop a custom material with post-industrial recycled PP content • Provided a more sustainable solution with 60% recycled content while maintaining the performance characteristics of prime PP • Expedited speed to market, delivering material in three weeks Gravi-Tech™ REC Recycled Formulation KEY REQUIREMENTS WHY AVIENT? All Rights Reserved https://www.avient.com/products/engineered-polymer-formulations/sustainable-formulations/gravi-tech-rec-recycled-formulations Packaging component manufacturer

All Rights Reserved https://www.avient.com/industries/packaging/industrial-packaging/pallets